About Us

The science of probiotics demands precision In colloboration with leading scientists and research partners from around the world, we deyelp
research-backed probiotics for outcomes across gastrointestinal, dermatolgical, oral, pediatric, and nutritional health

For humans, by science.

our process starts with microbial strain validation through biofermentation, stabilization, scale-up, and clinical research.

Strains

Biofermentation

Biofermentation

This-a metabolie process used by bacterla to generate enery for celgrowth and mutiplication-1s how we cuture our probiottc strains.
3acteria are sensitive. They must be cultured with care to ensure viablity. We optimize biofermentation conditions for pH, strain purity.
temperature, and 28 other factors.

Validation

Flow Cytometry

During this process, cells are selectively tagged with fluorescent"markers" and counted by a laser as they pass through a tube. Intesting for AFU (Active Fluorescent Units), flow cytometry is usedto calculate a more precise measurement of all viable, injured,and dead probiotic cells, including ones that are efficacious butnot necessarily culturable (and therefore, would not be countedin a traditional plated colony forming units (CFU) measurement-what you're probably used to seeing on probiotics labels).

Whole-Genome Sequencing

Our probiotics are among the first to undergo end-to-end,
whole-genome testing-the application of nanopore and
shotgun sequencing of microbial DNA to genetically validate
each strain and species.

Clinical Research

We partner with leading academic research institutions andnotable Primary Investigators to validate our rationally-designed probiotic formulations through double-blind,randomized, placebo-controlled clinical trials. Our humanclinical work, in combination with strain-specific clinicalresearch and our in vitro data generation, allows us to identifynovel endpoints and benefits for human health, whilecontributing advancements to the fields of microbiome andprobiotic science.

Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)

Bacteria are fragile; they’re sensitive to heat, oxygen, light, water, and they don’t do well without protection from stomach acids or bile. With this in mind,we test our products in SHIME®,the closest system developed to model human digestion and the gut.

Fig. 3— To evaluate the survival of our probiotics, we use a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)—the closest system developed to model digestion and the gut. It recreates the physiological conditions and biological processes (food uptake, peristalsis, digestive enzymes, bile acids, and time spent in each step) representative of the human gastrointestinal tract.

Our Products

Premium Quality

Our products are made with the highest quality ingredients and backed by scientific research.

Clinically Tested

Each product undergoes rigorous clinical testing to ensure safety and effectiveness.

Sustainable Sourcing

We are committed to sustainable and ethical sourcing practices for all our ingredients.

Shop DS-01® Daily Synbiotic Shop PDS-08® Pediatric Daily Synbiotic

Our Scientific and Clinical Advisory Boards

Our Scientific and Clinical Advisory Boards consist of scientists and clinicians across key fields, including microbiology, computational biology, host-microbe interactions, immunology, gastroenterology and women’s health. They lead labs, teach at world-renowned academic institutions, maintain regular patient-facing practices, and include members who serve as investigators from the NIH’s Human Microbiome Project. These scientists and clinicians have produced 2800+ publications and over 140,000 citations in peer-reviewed scientific journals and textbooks.